Study of Antihyperglycemic, Antihyperlipidemicand Nephroprotective Activity of CassiaAuriculata L. Extract in Streptozotocin InducedDiabetic Rats.

Abstract-
Present study was carried out to investigate
antihyperglycemic, antihyperlipidemic and
nephroprotective activity of hydroalcoholic extract
of aerial parts of Cassia auriculata L. (HACA) in
streptozotocin induced diabetes rats, to focus on its
possible mode of action and identification of possible
phytoconstituents responsible for the proposed
activity.
Experimental diabetes was induced in wistar rats
by single intraperitonial injection of streptozotocin
(65 mg/kg). Animals were divided in six groups
(n=6) and treated with variable doses of HACA
for 4 weeks. At the end of 4 weeks, fasting blood
glucose, oral glucose tolerance test (OGTT), blood
urea nitrogen (BUN), serum creatinine, serum total
proteins, serum albumin, lipid profile, glycosylated
haemoglobin, was determined. Antioxidant enzymes
of kidney were evaluated. Urine was analyzed for
albumin, total proteins and creatinine clearance.
Kidney of experimental animals was examined to
determine structural changes. The results of our study
demonstrate antihyperglycemic, antihyperlipidemic
and nephroprotective potential of aerial parts
of Cassia auriculata L. justifying its use in the
indigenous system of medicine.
Keywords – Streptozotocin, Cassia auriculata,
Diabetes, Antihyperlipidemic, Antioxidant
I. Introduction
Diabetes mellitus is a clinical syndrome characterized
by hyperglycemia due to absolute or relative
deficiency of insulin. Lack of insulin affects the
metabolism of carbohydrate, protein and fat leading
to significant disturbance of water and electrolyte
homeostasis. [1,2]. Current research is focused
Study of Antihyperglycemic, Antihyperlipidemic
and Nephroprotective Activity of Cassia
Auriculata L. Extract in Streptozotocin Induced
Diabetic Rats.
Deepti D.Bandawane*1, Neelam K. Mhetre2
*1 Department of Pharmacology,
P.E. Society’s Modern College of Pharmacy, Sector 21, Yamunanagar, Nigdi, Pune- 411 044, India.
[email protected]
on the development of newer drug leads from
phytoconstituents of medicinal plants which have
been used in traditional practices, so as to get more
potential and effective agents with lesser side effects
than existing hypoglycemic agents