Design And In Vitro Evaluation of NimesulideLoaded Solid Lipid Nanoparticles (SLN’s)

Abstract :
Purpose : The purpose of present investigation
was to prepare solid lipid nanoparticles
of Nimesulide (NSL) and to evaluate and
characterize the prepared optimum formulation.
Methods : This technique was selected on the
basis of production yield, ease of formulation and
practicability. For improving oral bioavailability,
Nimesulide loaded SLNs were developed using
glyceryl monostearate was the best lipid for NSL
SLNs. Polyvinyl alcohol was used as surfactant.
SLNs were characterized for particle size,
entrapment efficiency, drug loading, In-vitro
drug release measurements for the analysis of
polymorphic modifications.
Results : Particle size of SLNs was measured
by Malvern Zetasizer and under Projection
Microscope and was found to be in the limit
of 300-500 nm and also had almost round and
uniform shape. In-vitro release studies showed
that Nimesulide (NSL) was released from SLNs
in a sustained manner for all formulations.
Conclusions : Thus, it can be concluded that a
systematic formulation approach can be adopted
to reach an optimum point in the shortest time
with minimum efforts.
Keywords : Nanotechnology, Lipids,
Surfactants, entrapment efficiency, drug release.
Introduction1, 2:-
Nanotechnology is a field of applied science
and technology wherein the particles smaller
than 1 μm, normally 50-1000 nm are obtained
which also includes the development of
devices within that size range. This field
includes the applications from various scientific
disciplines such as materials science, applied
physics, colloidal science, pharmaceutical
sciences, supramolecular chemistry, electrical
engineering, device physics and even mechanical
engineering. In this technology the drug is not
only dissolved and entrapped, but also attached
to a nanoparticle matrix or encapsulated. Solid
Lipid nanoparticles (SLN) system includes the
surrounding of the drug by a lipid membrane by
confining it into a cavity. Depending upon the
method of preparation, solid lipid nanoparticles
can be obtained.