Treatment of diabetic foot ulcers with autologousbone marrow cells, platelets, fibrin glue andcollagen matrix

Abstract :
Objectives : To study the role of autologous
bone marrow in healing chronic diabetic wound
And to evaluate the cost effectiveness
Methods : Autologous Bone Marrow
aspirated under spinal anaesthesia and Bone
Marrow-total nucleated cells were separated
and concentrated. 100 mL peripheral blood were
taken and platelets and fibrin glue were prepared
according to standard procedures. Then it was
locally applied and regular dressing done. Pt
was followed for six weeks, with assessing the
wound every week.
Results : 35 patients were studied and 3
patients had complete closure of the wound. One
patient did not show significant improvement.
Rest all the patients had significant reduction of
wound size after 6 weeks.
Conclusion : Patients treated with autologus
bone marrow cells, platelets, fibrin glue and
collegan matrix did show significant reduction
in the wound size. Use of these components was
safe and effective and this treatment had been
cost effective.
Key Words : Bone Marrow, Platelets, Fibrin
Glue, Collegan Matrix
INTRODUCTION
Definition: Diabetic foot ulcers are defined as
foot affected by ulceration that is associated with
neuropathy and/or peripheral arterial disease of
the lower limb in a patient with diabetes [1].
Diabetic foot ulcers are also defined as:
neuropathic in the presence of peripheral
diabetic neuropathy and absence of ischemia;
ischemic if the patient presents peripheral artery
disease but no diabetic peripheral neuropathy;