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Art of Clinical Medicine

More than 400 years ago, the great English
thinker, philosopher, scientist, jurist and essayist

  • Sir Francis Bacon had said :
    “It is a pleasure to stand upon the shore, and
    to see ships tost upon the ea; a pleasure to stand
    in the window of a castle, and to see a battle and
    the adventures thereof below; but no pleasure is
    comparable to standing upon the vantage ground
    of truth and to see the errors, and wanderings,
    and mists, and tempests, in the vale below”.
    These magical words emerge as our guiding
    light. We must closely observe our errors and
    wanderings that traverse the vale we all inhabit,
    the magnificent valley of Medicine.
    The theme is simply being to identify the
    fault lines. This is to introspect and look at the
    ways to better them. Medicine of recent, has
    increasingly become a slave of metrics – of
    machines, statistical numbers and artifacts which
    nowadays appear to rule the hearts of physicians
    and surgeons. The evidence based medicine
    may look robust has some disadvantages also.
    We are too much dependent on evidence based
    medicine. A physician and surgeon must not
    forget a simple truth that a physician / a surgeon
    is treatment human beings, with a pulsating
    biological system set with its own genetic code,
    an ecosystem that is individual specific. If we still
    yield ground and practice old fashioned methods
    of touching, looking and listening, almost the
    once prized, magical skills of the doctor, we
    can swifty diagnose a peculiar walk, sluggish
    thyroid or murmuring heart valves, using just
    keen eyes, practiced hands and the stethoscope.
    This is called as a “Clinical Intuition”.
Volume2-Issue1_2

Role of ICT for Administration inEducational Institute

Abstract –
Information and Communication Technology
(ICT) has become essential part of educational
administration for quality enhancement and
fast work. The role of ICT becomes very
important in the field of education as the world
is rapidly moving into digital media. ICT
can be used in most of administrative tasks
such as student record and staff database.
ICT based administration is key part of
educational Institute as it reduces efforts for
time consuming and tedious work. Hence,
this paper addresses major functional areas
of ICT, its need, issues in implementation,
benefits and finally the implementation of
ICT in college.
Keywords – Information and Communication
Technology (ICT), staff administration, student
administration, functional areas, educational
institute
I. Introduction
Information and Communication Technology
(ICT) plays a very important role in
administration of education sector. ICT
can be used from student administration to
various resource administrations like staff
administration, general administration etc. ICT
includes technological tools and resources which
are used to communicate, create, distribute,
store and manage information. The technologies
include but not limited to computers, hardware,
network, software, television, equipments,
videoconferencing and electronic mail [4].
College administration can be made less
laborious and fast by application of ICT.
Existing resources in educational institute can be
well organized and utilized with the help of ICT.
Administrative task becomes easy by reducing
manual paper work.

Volume1-Issue2_10

Role of Corporate Social Responsibility inControlling Global Warming

Abstract –
Thenew Companies Act, 2013 has brought in
lot of innovative practices, one of which is the
compulsory Corporate Social Responsibility
Activity for companies which are having a net
worth above a certain amount. This article is
a attempt to correlate this Corporate Social
Responsibility with the crucial issue of Global
Warming and coming up with a practicable
solution of the issue.
Keywords – Corporate Social Responsibility,
Environment, Global Warming.
Introduction :
“We believe that the leading global companies
of 2020 will be those that provide goods and
services and reach new customers in ways
that address the world’s major challenges –
including poverty, climate change, resource
depletion, globalization, and demographic
shifts.” – Niall Fitzgerald, former CEO &
Chairman Unilever1

Volume1-Issue2_9

A Robust Hybrid Approach forBiometric Identification

Abstract
Identification of a person in real time has become
a crucial issue now a day. There are multiple ways
of biometric identification. There are limitations
using individual biometric system. Potential
approach to overcome some of these limitations
of individual solutions could be Vision & speech
based hybrid biometric identification.
Vision processing typically includes face
recognition, and speech processing includes
voice characterization along with gender
identification. The work presented here provides
the system design for such hybrid approach.
Functional components involved, scope of the
solution, and problems of individual biometric
identification approaches are explained.
Key words: – Biometric Identification, Hybrid
Approach, Vision processing, Speech processing
I. Introduction
Biometric Identification

  • One of the advanced methods for uniquely
    distinguishing individual persons
  • Has large applications in day to day real time
    operations
  • M as shown in Figure 1 the area where the
    hybrid system can be implemented.
  1. Banking and security sectors
  2. Aviation
  3. Various attandence system
  4. Transport system
Volume1-Issue2_8

Organogenesis and Somatic Embryogenesis ofJatropha curcas L.

Abstract
Jatropha curcas is a small bush who has attracted
the attention as an energy crop for the biodiesel
production. A number of reports have been
published regarding to the toxic J. curcas but
there is little information relating to non-toxic
J. curcas. A simple, high-frequency protocol
for plant regeneration through organogenesis
and somatic embryogenesis has been developed
in cultured explants of non-toxic Jatropha
curcas with different plant growth regulators.
When Thidiazuron was used at concentrations
of 3.5 and 4.5 μM, leaf explants showed the
best response, forming a highly organogenic
callus from which 78 and 64 shoots/explant
were obtained. However, when Benzyladenine
was combined with Indoleacteic acid, the
hypocotyl explants showed a greater capacity for
organogenesis compared with the leaf explant,
both in indirect organogenesis (112 ± 1.8 shoots/
explant) and in direct organogenesis (82 ±1.6
shoots/explant). Somatic embryogenesis was
induced directly from leaf explants which were
exposed to 8.9 μM of Benzyladenine + 5.6 μM
of 2,4-Dichlorophenoxyactic acid. After 12
weeks of culture, the embryos began to turn
green and eventually germinated. The shoots
were elongated (73%) in the presence of 2.8 μM
of Giberellic acid.
Keywords : Regeneration, biodiesel, plant growth
regulators, somatic embryos, adventitious
shoots, shoot elongation.
Introduction
The search of new sources for the alternative
energy production is one of the main objectives
of the international community. One subject that
has been receiving attention is the search of nonedible
crops that facilitate the biofuel production
in an efficient manner (Kumar et al 2010a, Kumar
et al 2010b). Among the existing biofuels we
found the biodiesel which can be obtained from
several sources such as rapeseed, sunflower,
soybean, oil palm, linseed, cotton seed and beef
tallow (Achten et al 2010). One of the candidate
crops is Jatropha curcas (J. curcas) which is a
multipurpose perennial shrub from the tropics
and subtropics of South America Achten et al
2010). J. curcas (Euphobiaceace) has attracted
the attention from various developmental
agencies due its medicinal properties, resistance
to various stresses and recently as an oilseed
crop for the biodiesel production given its high
oilseed content (40%) Martínez-Herrera et al
2010). One of the advantages of this species
is the fact that its seed is not consumed due
its toxicity and it can grow in low moisture
soils (Martínez-Herrera et al 2010). Mexico is
considered the center of origin of this species
and it is the only place were non-toxic cultivars
can be found, although they are not particularly
abundant (Sujatha et al 2005, Achten et al 2010,
Martínez-Herrera et al 2010). The byproducts
of non toxic cultivars can be used animal fodder
given its high protein content (Martínez-Herrera
et al 2010).

Volume1-Issue2_7

Indian Economy: Transition to Take Longer Time

Abstract
Indian economy is in a transition phase. After
years of slowing growth coupled with rising
fiscal deficiate and governments indebtedness
the country witness a crises like situation in
August 2013 when the rupee crashed and the
soverign credit rating was on the verge of loosing
its investment grade. It was no wonder that
experts drew parellels with 1991. The change in
the political scenario and policy making in 2014
was the key to pull the country out of immediate
danger. This change in direction created a
sence of celebrationparticullary on the Dalal
street, which although typical, was somewhat
premature. There is no doubt the economy has
changed direction, but a number of hurdles
including an unsupportive global economy and
a weak monsoon have slowed down the process.
The transition phase for the economy is likely to
be longer than earlier anticipated.
Key words : Inflation, Fiscal deficit

  1. Introduction
    Indian economy’s transition from a slowdown to
    high growth is proving to be a longer and harder
    journey than earlier envisaged due to numerous
    factors. The slowing down global growth isn’t
    helping, domestic reforms are taking time to
    fructify, the jammed up investment cycle is yet
    to pick up and challenges in agriculture have
    hampered rural consumption. The quick gains
    the economy made in last 18 months were
    mainly on account of favourable global trends
    including a sharp drop in commodity prices,
    particularly crude oil, and near zero interest rates
    in the major economies such as US, Japan and
    Germany.
Volume1-Issue2_6

Chemical Composition, Antioxidant, Cytotoxic andDNA Damage Protective Activities of Plectranthusmollis Essential Oils

Abstract
The essential oils were obtained by hydro-distillation from Plectranthus mollis and subjected to
phytochemical screening and gas chromatography-mass spectroscopy (GC-MS) to establish their
qualitative and quantitative compositions. Phytochemical investigations confirmed that the essential
oils are rich-source of phenols, flavonoids, ascorbic acid and carotenoids. The essential oils were
evaluated for their antioxidant and lipid-peroxidation inhibition activities besides their oxidative
DNA damage protection potentials. GC-MS data revealed a total of 40 compounds identified, which
accounted 98.4% of the total constituents. The major constituents were: Fenchone (31.43%) followed
by Piperitone oxide (17.79%), 3-Cyclopenten-1-one, 2-hydroxy-3-(3-methyl-2-butenyl) (8.19%),
Ζ-β-Farnesene (5.98%) and α-Humulene (5.86%). These essential oils exhibited broad-spectrum,
dose-dependent antioxidant potencies as evidenced by total-antioxidant-activity (TAA), 1,1-diphenyl-
2-picrylhydrazyl (DPPH) scavenging, and ferric reducing antioxidant power (FRAP) assays. They
showed significant inhibition of lipid peroxidation rate measured in terms of malondialdehyde (MDA)
content. These results hold significance, as lipid-peroxidation is considered as biological end-point
of oxidative damage and its inhibition as the most important index for antioxidant potential. The oils
successfully protected the DNA from Fenton’s reagent induced DNA damage. The essential oils of P.
mollis showed good anti-proliferative activity in a dose-dependent manner against human melanoma
cancer M-16 cell line, with only ~10% cell survival at 2 μL concentration.
Keywords – Plectranthus mollis; essential oils; antioxidants; cytotoxicity; lipid peroxidation; DNA
protection; human cancer cells.

  1. Introduction
    Various plant extracts and phytochemicals including essential oils are considered strong antioxidative
    agents and have been advocated as potent lead-compounds for these products. Essential oils are
    natural, volatile, complex secondary metabolites produced by aromatic plants and are characterized
    by their strong odour [1]. They are known for their broad-spectrum medicinal and commercial
    values. Plectranthus mollis (family Lamiaceae) is an annual erect herb, locally called Lal aghada,
    found throughout India and is used extensively as a vasoconstrictor, cardiac depressant, respiratory
    stimulant, fever-reducer, besides being also used for rheumatism, hemorrhage, mental retardation,
    snakebites as well as a general tonic
Volume1-Issue2_4

Design And In Vitro Evaluation of NimesulideLoaded Solid Lipid Nanoparticles (SLN’s)

Abstract :
Purpose : The purpose of present investigation
was to prepare solid lipid nanoparticles
of Nimesulide (NSL) and to evaluate and
characterize the prepared optimum formulation.
Methods : This technique was selected on the
basis of production yield, ease of formulation and
practicability. For improving oral bioavailability,
Nimesulide loaded SLNs were developed using
glyceryl monostearate was the best lipid for NSL
SLNs. Polyvinyl alcohol was used as surfactant.
SLNs were characterized for particle size,
entrapment efficiency, drug loading, In-vitro
drug release measurements for the analysis of
polymorphic modifications.
Results : Particle size of SLNs was measured
by Malvern Zetasizer and under Projection
Microscope and was found to be in the limit
of 300-500 nm and also had almost round and
uniform shape. In-vitro release studies showed
that Nimesulide (NSL) was released from SLNs
in a sustained manner for all formulations.
Conclusions : Thus, it can be concluded that a
systematic formulation approach can be adopted
to reach an optimum point in the shortest time
with minimum efforts.
Keywords : Nanotechnology, Lipids,
Surfactants, entrapment efficiency, drug release.
Introduction1, 2:-
Nanotechnology is a field of applied science
and technology wherein the particles smaller
than 1 μm, normally 50-1000 nm are obtained
which also includes the development of
devices within that size range. This field
includes the applications from various scientific
disciplines such as materials science, applied
physics, colloidal science, pharmaceutical
sciences, supramolecular chemistry, electrical
engineering, device physics and even mechanical
engineering. In this technology the drug is not
only dissolved and entrapped, but also attached
to a nanoparticle matrix or encapsulated. Solid
Lipid nanoparticles (SLN) system includes the
surrounding of the drug by a lipid membrane by
confining it into a cavity. Depending upon the
method of preparation, solid lipid nanoparticles
can be obtained.

Volume1-Issue2_3

Case Report : Laparoscopic Spleen PreservingDistal Pancreatectomy for Insulinoma

Abstract
We report a case of a 67-year-old male patient
with an insulinoma of pancreas at the junction
of body and tail. He underwent a laparoscopic
spleen preserving distal pancreatectomy. Patient
presented with episodes of giddiness and
drowsiness for past 4 months. There was also
history of tremor on exertion since 4 months.
His symptoms improved with intake of food.
During his episodes his blood sugar levels
ranging from 35 mg% – to 50 mg%. Patient was
thoroughly evaluated. USG abdomen and MRI
abdomen showed normal study. His fasting
serum insulin level raised with normal ACTH
and cortisol level. DOTA PET Scan suggestive
of focal octreotide receptor expressing lesion at
the junction of body and tail of pancreas. There
were no postoperative complications, and the
patient was discharged from the hospital on day

  1. The patient was ambulatory soon after the
    procedure. He was allowed to take oral liquids
    after 12 hrs post surgery, and his hospital stay
    was short; therefore, the surgery was judged to
    have been highly useful.
    Introduction
    Insulinoma is the most common neuroendocrine
    tumor of the pancreas. Peak incidence of
    occurrence is between 40 to 69 years. About
    40% – 90 % of tumors are nonfunctional.
    Rest of them manifest with evident hormonal
    symptoms. Of the functional tumors 70% are
    insulinoma, of which 90% are benign. Usually
    present with symptoms like anxiety, confusion,
    dizziness, headaches, and sweating. Treatment
    for insulinoma is surgical excision, however
    before surgery; symptoms of excess hormones
    must be corrected. Patients with neuroendocrine
    tumor after surgery generally do well for years.
    Distal pancreatectomy (DP) is the removal
    of the pancreatic tissue at the left side of the
    superior mesenteric vein and it is traditionally
    approached by an open or laparoscopic exposure.
    Preservation of the spleen is optional but appears
    to have a better immunological outcome.
Volume1-Issue2_2

ICT in Higher Education:A Case Study

Abstract :
Traditional methods of teaching have been greatly
augmented by the availability of newer technologies
in the field of communication. We investigated
various aspects of inclusion of ICT in teaching
learning process at college level by conducting
a survey. We found that students have adequate
digital access, most prefer inclusion of 30-60% ICT
in teaching and need to be counseled regarding ill
effects of prolonged exposure to digital media.
Keywords : ICT, higher education, survey, internet,
teaching
I. Introduction
The draft of National Policy on Education framed
in 1986, and modified in 1992 stressed upon using
Technology in improving the quality of education.
The IT/ ICT policy in Education aims at preparing
youth to develop a knowledge society for all round
socio-economic development of the nation and
enhanced global competitiveness. The IT/ICT literate
community can benefit from IT/ICT and contribute to
nation building [1]. Multiple factors have encouraged
the adoption of ICT in teaching and learning. There
is a growing need to explore how inclusion of ICT
can improve program delivery, introduce flexibility
for customized educational programs to meet the
needs of individual learners and how internet and
WWW can provide tools for information access
and communication [2]. The use of the internet has
increased exponentially to support teaching and
learning, as more and more educational organizations
are recognizing its potential [3]. Students use the
internet information systems for both academic and
non-academic work [4]. In this work a survey was
carried out to find out the outcome of use of ICT
based educational techniques at undergraduate and
postgraduate level.

Volume1-Issue1_11